PRODUCT : URIFUR SR

CATEGORY :
URINARY ANTI-INFECTIVE
Composition :
Nitrofurantoin 100 mg Sustained Release Tablets.
Indication
Adult doses of nitrofurantoin for a urinary tract infections can be 100mg two times daily, for five to seven days. For less severe cases of UTIs, the dosage may be prescribed as shortened to 3 days. The pediatric dose is 5 - 7 mg/kg/day in four divided doses. Nitrofurantoin should be taken with food, as this improves the absorption of the drug by 45%.
Dosage
1 tablets b.i.d
Contraindications
Anuria, oliguria, impaired renal functions.
Precautions
Acidify urine. Monitor pulmonary, renal and hepatic function during long term therapy. Anaemia. Asthma. Diabetes, electrolyte imbalence. Vit deficiency.
Mechanism Of Action
Nitrofurantoin is an antibiotic It is usually used in treating urinary tract infection. It is often used against E. coli. Bacteria reduce nitrofurantoin more rapidly than do mammalian cells, andthis is thought to account for the selective antimicrobial activity of the compound. Bacteria that are susceptible to the drug rarely become resistant during therapy. Nitrofurantoin is active against many strains of E.Coli and enterococci. However most species of Proteus and Pseudomonas and many species of Enterobacter and Klebsiella are resistant.

Nitrofurantoin is bateriostatic for most susceptible microorganism at concentration of = 32 g/mL or less(MIC) and is bacteriocidal at concentration of = 100 g/mL. The antibacterial activity is higher in an acidic urine.

The drug works by damaging bacterial DNA,since its reduced form is highly reactive. This is made possible by the rapid reduction of nitrofurantoin inside the bacterial cell by flavoproteins ( nitrofuran reductase) to multiple reactive intermediates that attack ribosomal proteins, DNA,respiration, pyruvate metabolism and other macromolecules within the cell.
DISCLAIMER : This product is available only in India against valid prescription from a Registered Medical Practitioner. This is not an offer for sale.